PRL and benign prostatic hyperplasia: Based on these findings, Pb–PRL mice appear to be a good preclinical model of human BPH, and accordingly, it was successfully used to determine the effects of milk diet (Bernichtein et al., 2015b), dietary calcium and vitamin D (Bernichtein et al., 2017), and hexanic lipidosterolic extract of Saw Palmetto S. repens (Bernichtein et al., 2015a) on disease progression.