PRL and benign prostatic hyperplasia: Compared to other rodent models of BPH (Wennbo et al., 1997; Van Coppenolle et al., 2001; Nicholson et al., 2012), Pb–PRL mice do not exhibit elevated serum levels of androgens (Kindblom et al., 2003), which better mimics the context of patients developing BPH.