CFH and Alzheimer disease: For example, the up-regulation of both miRNA-9 and miRNA-146a in AD has been shown to down-regulate the expression of the innate-immune glycoprotein complement factor H (CFH), and this stimulates runaway innate-immune and inflammatory signalling in AD that directly impacts mitochondrial-based energy-generating capacities (Alexandrov et al., 2012; Bergman et al., 2016; Sorensen et al., 2016; Zhao et al., 2016).