GRIA1 and bipolar disorder: A mouse line with deficient AMPA-type glutamate receptor GluA1 subunits [the Gria1-/- mouse line (Zamanillo et al., 1999)] has been proposed as an animal model for hyperactive disorders, including schizoaffective disorder and bipolar disorder with mania (Fitzgerald et al., 2010; Barkus et al., 2011; Procaccini et al., 2011).