This is based on (1) robust novelty-induced hyperactivity that is eventually habituated, leading to unaltered diurnal home-cage activity in the Gria1-/- mice (Vekovischeva et al., 2001; Fitzgerald et al., 2010; Sanderson et al., 2010; Procaccini et al., 2011), (2) consistent attenuation of this behavior by chronic treatment with drugs having antimanic efficacy in patients (Maksimovic et al., 2014a,b), and (3) linkage equilibrium of GRIA1-gene polymorphisms in psychotic disorders (Ripke et al., 2013, 2014; Devor et al., 2017). This evidence concerns the gene GRIA1 and psychotic disorder.