NOS2 and diabetes mellitus: In streptozotocin (STZ)-induced diabetes in Long-Evans rats, aminoguanidine and 1400W (a more selective and potent iNOS inhibitor) restored light- and glial-evoked vasodilation in the retina, suggesting a role for iNOS in the loss of functional hyperemia due to aberrant glia-to-vessel signaling (Mishra and Newman, 2010).