The multiple linear regression analysis showed the significant correlations between the presence of APOE ε4 allele and the scores of the delayed memory subdomain if education were adjusted (Model 6, t = -2.091, p = 0.037) or if age, gender, and education were adjusted (Model 7, t = -2.105, p = 0.035) or if age, gender, education, and BMI were adjusted (Model 8, t = -2.097, p = 0.036) or if age, gender, education, BMI, and biochemical factors (HTN, DM, FBG, TC, TG, UA, Hb, ALT, Cr) were adjusted (Model 9, t = -2.162, p = 0.031). The gene discussed is GPT; the disease is hypertensive disorder.