There were no significant differences in age (z = -0.059, p = 0.953), gender (x2 = 0.019, p = 0.889), education levels (z = -1.658, p = 0.097), and comorbidities such as hypertension (x2 = 0.095, p = 0.758) and diabetes mellitus (x2 = 0.153, p = 0.696) between APOE ε4 carrier and non-ε4 carrier groups. The gene discussed is APOE; the disease is diabetes mellitus.