PLCG2 and autoinflammatory syndrome: Enhanced amyloidosis associated with FAD mutations parallel the mutation-induced upregulation of innate immune pathways that mediate pathologies in inherited autoinflammatory syndromes, including Familial Mediterranean fever, TNF receptor- associated periodic syndrome, Muckle–Wells syndrome, Blau syndrome, pyogenic arthritis, pyoderma gangrenosum and acne syndrome, early-onset enterocolitis, autoinflammation and PLCγ2- associated antibody deficiency and immune dysregulation, and proteasome-associated autoinflammatory syndromes (Martinon and Aksentijevich, 2015).