MAPT and frontotemporal dementia: In vitro studies in transgenic mice expressing pathological human tau (V337M mutation), which is one of the main pathological hallmarks of FTD, have shown both AMPA and NMDA receptor hypofunction in the ventral striatum and insular cortex, which were reversible after the administration of cycloserine, an NMDA receptor co-agonist (Warmus et al., 2014).