Even single exercise sessions, which increases the production of endogenous opioids (Geneen et al., 2017), angiogenesis factors (such as vascular endothelial growth factor [VEGF], hypoxia-induced 1 alpha factor [HIF-1α] and erythropoietin [EPO]) (Ribeiro et al., 2017) appear to be healthy, and they protect against hyperglycemia peaks (Lang Lehrskov et al., 2018) in humans. This evidence concerns the gene HIF1A and Hyperglycemia.