SETD2 and cancer: In other non-neuronal models of cancer, NfKB has been linked to inhibition of nuclear receptor binding SET domain protein 1 (NSD1) and SET domain containing 2 (SetD2), two H3K36 histone methyltransferases, which are linked to longevity, though not general to chromatin silencing (Sen et al., 2015) (Figure 3C).