As previously shown by several groups (Hohmeier et al., 2000; Millán et al., 2010), the INS-1-derived cell line (832/13), called herein insulinoma, expressed key components of the glucose sensing machinery such as GLUT2 and GK, as well as they are responsive to glucose by insulin secretion at physiological range. The gene discussed is GK; the disease is pancreatic insulinoma.