Fatty acids may activate Toll-like receptor 4 (TLR4) signaling in adipocytes and macrophages and induce inflammatory signaling (Shi et al., 2006), and mice lacking TLR4 were shown to be protected against high-fat diet-induced obesity and insulin resistance (Poggi et al., 2007; Davis et al., 2008). The gene discussed is TLR4; the disease is Obesity.