GRIN2C and isolated focal cortical dysplasia type II: Interestingly, cortical resections from patients with tuberous sclerosis and FCD type II also demonstrated higher expression levels of NR2C as compared with control fetal or adult samples (Lozovaya et al., 2014); in addition to this, patch-clamp recordings on these cortical resections demonstrated the contribution of NR2C to NMDA currents confirming the potential role of NR2C to epileptogenesis in mTORpathies.