The PPI network analysis revealed that MAP3K5, PIK3R2, RAC1, PIP4K2C, and PPP2R2B participated in various biological progress such as single-organism cellular process or single-organism transport, and MAP3K5, PIK3R2, RAC1, PIP4K2C, and BAD participated in neurotrophin signaling pathway, which may play a critical influence in the pathogenesis of depression. This evidence concerns the gene PIK3R2 and depressive disorder.