PTEN and colorectal carcinoma: In this study, we found that mir-26a was overexpressed in CRC tissues, CRC-derived cell lines, and in samples listed in the TCGA database; furthermore, we found that mir-26a also was overexpressed in a CRC mouse model and that, when overexpressed in CRC-derive cell lines, it maintains proliferation and enhance migration via direct regulation of PTEN; moreover, mir-26a affected phosphorylation levels of AKT that is an effector of PTEN-PI3K pathway (Fig. 7).