But the evidence from lung and colorectal cancer is most interesting: In lung cancer, PTEN is downregulated also by miR-21 [30], miR-205 [31], and miR-92a [32]; while in colorectal cancer, it is regulated by miR-21 [33], miR-92a [34] and miR-106b [35]. This evidence concerns the gene PTEN and lung cancer.