IL17A and diabetes mellitus: Moreover, the higher percentage of baseline Th17 lymphocytes found in the FDR group fits to the concept of the proinflammatory state preceding/contributing to diabetes onset, since TH17 T-cells producing IL-17 were associated with proinflammatory reactions and diabetic complications [23] and increased levels of TH1 and TH17 circulating T-cells were reported also in T2DM subjects [4, 24, 25].