BRI3 and hepatocellular carcinoma: In order toidentify novel transcriptional targets of the Wnt/β-cateninsignaling pathway, these transcriptome profile analyseswere performed in our laboratory using stable Huh7(hepatocellular carcinoma) cell lines overexpressing amutant form of β-catenin, which is degradation-resistant.BRI3 was among the several putative Wnt/β-catenin targetgenes that were detected with differential expression profilesupon β-catenin induction in the Huh7 cell line.