HDAC3 and fatty liver disease: Indeed, knockouts and various knockin mutants of NCoR, SMRT, and HDAC3 have demonstrated hepatic steatosis phenotypes (Knutson et al., 2008; Mottis et al., 2013; Shimizu et al., 2015; Sun et al., 2012), in contrast to the lipid overload-protected phenotype observed here with hepatocyte Bcl6 ablation.