TGFB1 and Hepatic fibrosis: Smad7 is known as an inhibitory smad (I‐smad) or a protective smad that switches off the TGFβ/smad signalling pathway.50 In the context of hepatic fibrosis, smad7 negatively mediates smad3‐induced fibrogenesis.51 Earlier reports have shown that TGFβ3 may regulate smad7 proteins through the TGFβ/smad signalling pathway to minimize extrinsic scarring 52 and hepatic fibrosis.53 Our main interest was to investigate the relationship between TGFβ3 and smad7 activation in MI.