Smad7 is known as an inhibitory smad (I‐smad) or a protective smad that switches off the TGFβ/smad signalling pathway.50 In the context of hepatic fibrosis, smad7 negatively mediates smad3‐induced fibrogenesis.51 Earlier reports have shown that TGFβ3 may regulate smad7 proteins through the TGFβ/smad signalling pathway to minimize extrinsic scarring 52 and hepatic fibrosis.53 Our main interest was to investigate the relationship between TGFβ3 and smad7 activation in MI. This evidence concerns the gene SMAD3 and Hepatic fibrosis.