TGFB3 and fibrosis: Fibrosis is mainly characterized by migration and proliferation of CFs.33, 34 It had been reported that TGFβ3 could attenuate CFs proliferation and differentiation in skin.36 In addition, Simon N and Waddington, et al provided strong evidence that the presence of mutTGFβ3 at the wound site significantly reduced the amount of CFs, retarded CFs migration and attenuated collagen synthesis within the wound area.9 In this study, we found that TGFβ3 increased migration, proliferation and collagen synthesis at 5 ng/mL and attenuated migration, proliferation and collagen synthesis at 10 and 50 ng/mL.