TP53 and neoplasm: In tumour cells, mortalin overexpression can inhibit P53 activity and activate telomerase and hnRNP‐K to promote tumour progression.36 In addition, it can inhibit apoptosis by suppressing conformational changes in P53 and BAX.37 As an integral part of the ATPase complex, mortalin also plays an important role in maintaining mitochondrial homeostasis, which is critical for the translocation of most mitochondrial membrane and matrix proteins.38, 39 The energy generated by mitochondria is essential for the process of tumour development.40