It also regulates cell differentiation, inflammation and other pathological processes.18, 19 NF‐κB has been implicated in various diseases such as allergies,20 neurodegenerative diseases,21, 22 ophthalmic diseases23, 24 and cancer.25, 26, 27, 28 There are five members of the NF‐κB family, p65 (RelA), RelB, c‐Rel, p105/p50 (NF‐κB1) and p100/52 (NF‐κB2).29 NF‐κB p65 subunit is considered as the most potent transcriptional activator of the family.30 The gene discussed is NFKB1; the disease is allergic disease.