It regulates cell proliferation through interacting with a variety of molecules such as P53, GRP94 and VDAC, and participates in a number of molecular pathways.32, 33, 34 Studies show that mortalin expression is elevated in some tumour cells and tissues.35 Mortalin overexpression promotes tumorigenesis by inhibiting tumour cells apoptosis and promoting proliferation. This evidence concerns the gene HSP90B1 and neoplasm.