TSPAN8 and breast cancer: However, it is noteworthy that treatment of the parental MTPa cells with EVs released by the MTPa‐Tspan8 cells revealed their ability to suppress the expression of p120‐catenin and Twist encoding genes, and to diminish the expression of β‐catenin target genes in the parental cells, adding strength to the hypothesis that Tspan8 impacts the EV amount and may have a role in the regulation of EV content and function in breast cancer (Figure 6F).