Indeed, our present data with divalent Ab as mentioned above and the complete lack of EV endocytosis previously observed in melanoma cells in which CD9 was silenced in both entities (cells and/or EVs), suggest it (Figure 1C).23 It will be of interest to investigate the CD9 cis/trans‐dimerization by co‐immunoprecipitation using engineered CD9 proteins associated with cells and EVs with distinct epitope tags. Here, CD9 is linked to melanoma.