By monitoring the internalization of melanoma‐derived EVs and the intracellular routes of their content, particularly CD9 (see below), we discovered that EV‐associated proteins are transported into the nucleus of the host cell through late endosomes entering the nucleoplasmic reticulum (Figure 1A).23 Therein, EV‐associated cargo molecules can modify the gene expression of the host cells. Here, CD9 is linked to melanoma.