The mean (SD) T-tau and P-tau(181) concentrations were significantly higher in the AD group (722.7 (529.1) pg/mL; 72.1 (42.3) pg/mL) compared with healthy controls (326.6 (90.8) pg/mL; 51.1 (11.9) pg/mL) and the FTLD group (464.7 (344.1) pg/mL; 51.3 (24.1) pg/mL). This evidence concerns the gene MAPT and Alzheimer disease.