Our previous studies demonstrated that extract of China camellia inhibited tyrosinase activity and proliferation of melanocytes.18 Moreover, camellianin A exhibits potent antioxidant activity,26, 27 while oxidative stress can cause hyperpigmentation.28 Thus, both antioxidant and inhibition of melanogenesis properties of China camellia can contribute to improvements in pigmentation in melasma following the treatments with the test cream. Here, TYR is linked to freckles.