S100A4 mediates breast cancer metastasis, and its expression is controlled via the β‐catenin pathway (Bresnick et al., 2015); therefore, high levels of KLK6 could activate the β‐catenin pathway as reported in keratinocytes (Klucky et al., 2007), to drive the expression of S100A4. The gene discussed is KLK6; the disease is breast carcinoma.