A SNP located in a distal enhancer of lncRNA PCAT1 (prostate cancer associated transcript 1) alters the binding of its transcription factors ONECUT2 (one cut homeobox 2) and androgen receptor (AR) to the enhancer and PCAT1 promoter, thereby affecting the expression of PCAT1 which is involved in the development and progression of prostate cancer.26 This evidence concerns the gene AR and Familial prostate cancer.