ERBB2 and neoplasm: The association with increased pEGF-R [13], ErbB2 [28], and pAkt [29] signaling in the tumor epithelium, and with multiple signs of a particularly active tumor stroma response [18, 19], such as decreased stroma androgen receptors [30] and caveolin-1 [31], increased angiogenesis [15], high stroma hyaluronic acid [32] and a M2-macrophage (CD163+) [33] and mast cell- [34] associated inflammation suggest several potential targets that deserve future attention.