They also had higher hyaluronic acid staining in tumor stroma (9 vs. 7, P < 0.01), more tumor infiltrating CD163 + macrophages (25 vs. 19, P < 0.05), reduced stroma androgen receptors (42 vs. 52, P < 0.05) and reduced caveolin-1 (2 vs. 3, P < 0.05). This evidence concerns the gene CD163 and neoplasm.