NR1I2 and Crohn disease: Moreover, in a study that used microarray and pathway analysis to examine the effect of dietary curcumin and rutin on colonic inflammation, the data suggested that the reduction in colonic inflammation seen in a mouse model of Crohn’s disease may be attributed to an up-regulation of xenobiotic metabolism and a down regulation of pro-inflammatory pathways, mediated by PXR activation of RXR33.