Notably, preventing ZKSCAN3 phosphorylation by mutating T153, a target site of JNK2/p38 MAPK upon PKCδ activation14, abolished PLX4720-induced ZKSCAN3 translocation (Supplementary Fig. 4c), highlighting a conserved regulation of ZKSCAN3 in BRAFV600E melanoma. The gene discussed is PRKCD; the disease is melanoma.