Therefore, despite the identification of some canonical FMRP targets by the BONLAC screens, the bulk of the proteins that change consistently were not previously identified as top FMRP mRNA targets, suggesting that the de novo proteome under both steady state and activity-dependent conditions is not chiefly comprised of FMRP mRNA targets in FXS model mice under our experimental conditions. The gene discussed is FMR1; the disease is fragile X syndrome.