We next investigated the potential role of SRC-1 in humans by interrogating exome sequencing and targeted resequencing data on 2548 European ancestry individuals with severe, early-onset obesity (mean body mass index [BMI] standard deviation score = 3; age of onset < 10 years) and 1117 ancestry-matched controls24. This evidence concerns the gene NCOA1 and obesity due to melanocortin 4 receptor deficiency.