ZFHX3 and Familial prostate cancer: For ZFHX3, its loss of function is relatively common in advanced prostate cancer, as ZFHX3 is one of the most frequently mutated genes in prostate cancer; most tumors carrying ZFHX3 mutations are metastases, high-grade tumors, and/or castration-resistant tumors; and many of the mutations are truncating mutations19,33,34.