Importantly, repression of MYC indeed plays a causal role in ZFHX3-mediated suppression of cell proliferation in prostate cancer, as silencing MYC in C4-2B cells prevented ZFHX3 deletion from increasing cell proliferation in both SRB and colony formation assays (Fig. 3), and this remained true even when MYC expression was slightly reduced to a level comparable to that of control cells (Fig. 3). Here, ZFHX3 is linked to prostate cancer.