Although one region of the MYC promoter was bound by both ZFHX3 and ERβ, another region was only bound by ZFHX3 and not by ERβ (Fig. 5), further indicating that ZFHX3 is a bona fide repressor of MYC transcription in prostate cancer cells. This evidence concerns the gene ZFHX3 and Familial prostate cancer.