FOXO1 and Familial prostate cancer: For example, a previous study demonstrated that ERβ interacts with KLF5 and CBP to induce FOXO1 transcription to suppress the proliferation of AR-negative prostate cancer cells21, but it is unknown whether KLF5 and CBP are also involved in the ERβ-ZFHX3 interaction in AR-positive prostate cancer cells.