ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Indeed, organoid treatment with the ABL inhibitor imatinib yielded negligible inhibition (IC50 imatinib = 4 or 6 μM for CRC0177 and CRC0254, respectively; Fig 7D) while the positive control (CML cell line K562) worked (Appendix Fig S11E), underscoring the value of INKA ranking for drug response prediction.