NDUFS4 and Leber hereditary optic neuropathy: In addition, these mice also show a LHON phenotype characterized by RGC dysfunction starting from P16 to P20 and leading to a detectable RGC death after P42 (Yu et al, 2015; Song et al, 2017), which makes the Ndufs4 knockout line a good model to study the effect of miR‐181a/b inactivation in LHON.