NDR1/2 silencing also decreased the migratory and invasive properties in RASSF1A-null HBEC as illustrated for H1299 (Additional file 2: Figure S2A/Figure S2B), A549 (Additional file 2: Figure S2A/Figure S2B) and H1650 lung cancer cells (Additional file 2: Figure S2A/Figure S2B, and Additional file 3: Movie S1/ Additional file 4: Movie S2 for siNeg and siNDR2 respectively) again, without leading to cell death (Additional file 2: Figure S2C, except for NDR2 silencing in H1650 cells). The gene discussed is RASSF1; the disease is lung cancer.