NOS2 and neoplasm: One of the ways MDSCs contribute to immunosuppression in the tumor microenvironment is by generating ROS, Arginase 1, free radicals and cytokines to suppress host CD4+ and CD8+ Tcell responses [8, 56, 57].It is believed that Arginase and iNOS function synergistically in MDSCs to inhibit antigen-specific T cell response [58, 59].