For example, TRIM proteins including TRIM59 [9], TRIM37 [10], TRIM25 [11], TRIM65 [12] and TRIM27 [13] were shown to be involved in gastric, breast, prostate, bladder urothelial and colorectal cancer through the ubiquitin-mediated degradation, indicating crucial roles of the TRIM family in tumorigenesis. Here, TRAT1 is linked to colorectal cancer.