Mechanistically, TRIM47 promotes the ubiquitination and degration of SMAD4 by interacting with SMAD4, and further increases the levels of C-C motif chemokine ligand 15 (CCL15) and C-C motif chemokine receptor 1 (CCR1), ultimately causing poor outcome of colorectal cancer. The gene discussed is CCL15; the disease is colorectal cancer.