When Zeb1 expression was normalized to that of Fbxo45 (Fig. 7 j), but not Siah1 (Fig. 7 i), the DFS of colon cancer patients with higher Zeb1/Siah1 levels (Fig. 7 j) was statistically significantly reduced compared to patients with lower values. Here, FBXO45 is linked to colonic neoplasm.