Approximately, no more than one fourth of individuals with a clinical diagnosis of PFBC are found to have a heterozygous pathogenic variant in one of the four genes known to cause autosomal dominant PFBC: SLC20A2, PDGFRB, PDGFB and XPR1, and some may have mutations in the MYORG gene related to autosomal recessive PFBC [6]. The gene discussed is PDGFRB; the disease is bilateral striopallidodentate calcinosis.