MMP12 and asthma: Several studies using these experimental models of asthma have shown functional alterations in the resistance and elasticity of the respiratory system associated with inflammatory eosinophilic infiltrates; expression of Th2 and Th17 cytokines, MMP-9-, MMP-12-, TIMP-1-, and TGF-β-positive cells; increased deposition of actin, collagen, and elastic fibers, and increased mucus production in the airways and lung tissues [57,59,60,69,85].