DCN and asthma: In a mouse model of asthma exacerbated with lipopolysaccharide (LPS), Camargo et al. showed an increased number of cells positive for MMP-9, MMP-12, TIMP-1, and TGF-β, as well as an increased volume fraction of collagen fibers I and III, decorin, actin, biglycan, lumican, and fibronectin in the lung tissue [57].