FN1 and chronic obstructive pulmonary disease: Although the physiopathological mechanisms of ECM remodeling among asthma, COPD and ARDS are completely different, the ECM remodeling also requires the action of mechanical forces generated by the migration or contraction of myofibroblasts, by themselves, and the presence of fibronectin, initially produced by macrophages, which is responsible for the adhesion of cells to the matrix.