AKT1 and glioblastoma: Umesh et al. went further, revealing that the microenvironmental rigidity dependency of GBM tumor cell behavior occurs via the alteration of EGFR-dependent signaling [80]; in particular, it was demonstrated that an enhanced environmental stiffness modulates expression and phosphorylation of EGFR and its downstream effector Akt, also affecting a wide range of other signals along the EGFR pathway involved in proliferation.