Interestingly, Zhang et al. showed that a selective agonist of mGluR3 VU0155041 suppressed cell proliferation of the glioblastoma cell line LN through the suppression of Gli-1 transcription factor, suggesting this pathway as a possible key element in the mGluR4 control of GBM cell growth [66], suggesting this receptor subtype as a potential target for glioblastoma therapy. This evidence concerns the gene GRM4 and glioblastoma.