Interestingly, the finding that the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subunit GluR1 associates with integrin β1 suggests that α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) might act as membrane-associated cytoskeleton anchors for localized signaling at focal adhesion complexes [30] and, therefore, might play an important role in GBM cell migration. This evidence concerns the gene GRIA1 and glioblastoma.