EIF2AK3 and Hypoglycemia: Interestingly, while PERK and IRE1α are not required for Th17 differentiation, as their inhibition does not preclude Th17 differentiation [55,83], inhibition of PERK and IRE1α mitigates the effects of cellular stress on Th17 differentiation caused by reduced glucose metabolism or hypoglycemia and changed ionic pressure, respectively [78].