Beside playing an important physiological role in the stimulation of cell proliferation [44,45], H2O2 may also induce apoptosis associated with increased expression of p53, Puma, Noxa, and Bax in several cell types, including colon cancer and human cervical carcinoma HeLa cells [46,47]. The gene discussed is PMAIP1; the disease is malignant colon neoplasm.