Therefore, we examined the changes of protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and Nrf2 in uterine tissue of patients with benign (polyps and myomas), premalignant (hyperplasia simplex and hyperplasia complex), and malignant (adenocarcinoma) transformations. The gene discussed is CAT; the disease is adenocarcinoma.