Since FOXM1 overexpression induces neoplastic transformation of breast epithelia [41], prostate epithelia [42], non-small cell lung cancer-derived cells [43], and oral cavity and esophageal epithelia [11, 14], we silenced FOXM1 expression by introducing FOXM1-targeting short-hairpin RNAs (shRNA) into SCC-25 cells (S1B Fig). This evidence concerns the gene FOXM1 and non-small cell lung carcinoma.