Conversely, overexpression of FOXM1 (SCC-25 FOXM1 #2) in SCC-25 cells increased target gene transcripts involved in tumorigenesis (VEGFA and AURKB; Fig 4C and S1C Fig) and decreased those related to tumor suppression (TRAIL Receptor 1 and 2; Fig 4D and S1D Fig). The gene discussed is VEGFA; the disease is neoplasm.