GSK3B and Hyperglycemia: Comparison of WT, Akita or placebo and/or tamoxifen treated Akita GSK3βfl/flCre+ mice demonstrated that neither the presence of the floxed allele nor cardiac specific deletion of GSK3β had an effect on the level of hyperglycemia and the decrease in body weight of Akita type 1 diabetic mice (Table 2).