There was significant overlap between differential gene expression in IKZF1-mutated B-ALL and early gene expression changes in B3 cells at 0 to 2 h after Ikaros induction (Fig 1F, odds ratio = 2.53, adjusted [adj.] P = 0.02 for the 200 top differentially expressed genes). The gene discussed is IKZF1; the disease is precursor B-cell acute lymphoblastic leukemia.