In addition to mucins, other goblet cell‐secreted molecules such as trefoil factor 3 (TFF3) and resistin‐like molecule β (RELMβ) are also crucial mucus components, contributing to the barrier functionality of mucus.2, 5 TFF3 is known to be of paramount importance for epithelial restitution and mucosal healing.8 It is reported that TFF3‐deficiency increased colitis susceptibility and impaired normal mucosal repair in dextran sulfate sodium‐administrated mice.9 RELMβ was confirmed to be implicated in dampening of intestinal inflammation and antagonizing nematode infection in the gut.10, 11. The gene discussed is TFF3; the disease is colitis.