PSPH also acts as a positive regulator and is involved in the malignancy of a variety of cancers, including phyllodes tumor,11 breast cancer,12 hepatocellular carcinoma,13 and Ewing sarcoma,14 because the PSPH gene is stimulated during tumorigenesis and metastasis, which leads to the production of greater amounts of L‐serine.15 Although accumulating literature suggests that PSPH may be a critical regulator in the progression of human cancers, the role of PSPH dysregulation and its underlying molecular mechanism in NSCLC progression has not been explored. This evidence concerns the gene PSPH and cancer.