DPYD and Hyperammonemia: Two additional genes, ORNT2 and ORNT3, encode mitochondrial membrane transporters that act in parallel with the classical urea cycle ornithine transporter ORNT1.11, 12 DPYD does not appear in Table S1 because DPYD deficiency has not been associated with 5‐FU‐induced hyperammonemia, despite its association with 5‐FU‐induced neurotoxicity.