iGluRs are divided into three subfamilies on the basis of the structural similarity: N‐methyl‐d‐aspartate (NMDA), alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐iso‐xazolepropionic acid and kainate receptors (KA‐R).1 Glutamate receptor ionotropic, kainate 3 (GRIK3) is the member of the ionotropic glutamate KA‐R subfamily, a branch of glutamate receptor family, which plays a critical role in synaptic potentiation—an essential process for learning and memory.2, 3, 4, 5, 6 To our knowledge, few studies have reported on the association of GRIK3 with cancer. The gene discussed is GRIK3; the disease is cancer.