SDHB and pituitary gland adenoma: Other SDHB‐associated tumors include RCC, although the risk for this manifestation seems low, varying between 4.7% and 8%.21, 40 GISTs are reported to occur in approximately 2% of SDHB carriers.51 Pituitary adenoma have been reported in nine cases, but only three had proven LoH (loss of heterozygosity) and abnormal SDHB expression, thus confirming involvement of SDHB mutation.24 Tufton et al reported a case of a SDHB mutation carrier with pituitary carcinoma.52