Kiss et al showed that the tumor suppressor gene P16 was hypermethylated in SDHB mutated tumor tissue samples as opposed to RET‐, VHL‐ or NF‐related PGL/PCC.90P16 is an inhibitor of cyclin‐dependent kinases and plays an important role in cell cycle regulation by decelerating the cells progression from G1 phase to S phase, and acts therefore as a tumor suppressor. Here, VHL is linked to neoplasm.